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Center for Physiology and Biophysics: News of the Day
  1. The cellular response that protects pigs from COVID-19
    Studies since the start of the pandemic have noted that pigs exposed to the coronavirus don't show clinical signs of disease nor do they transmit the virus to other animals. Scientists have uncovered important clues that shed light on why pigs don't get sick, and the discovery could lead to better treatments for COVID-19 in humans.

  2. Research in mice identifies neurons that control locomotion
    For more than a century, scientists have known that while the commands that initiate movement come from the brain, the neurons that control locomotion once movement is underway reside within the spinal cord. Researchers now report that, in mice, they have identified one particular type of neuron that is both necessary and sufficient for regulating this type of movement. These neurons are called ventral spinocerebellar tract neurons (VSCTs).

  3. Old neurons can block neurogenesis in mice
    Destroying senescent cells in the aging stem cell niche enhances hippocampal neurogenesis and cognitive function in mice, researchers report.

  4. Researchers simulate behavior of living 'minimal cell' in three dimensions
    Scientists report that they have built a living 'minimal cell' with a genome stripped down to its barest essentials -- and a computer model of the cell that mirrors its behavior. By refining and testing their model, the scientists say they are developing a system for predicting how changes to the genomes, living conditions or physical characteristics of live cells will alter how they function.

  5. Newly discovered DNA repair mechanisms point to potential therapy targets for cancer and neurodegenerative diseases
    Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and machine learning systems that can identify and classify DNA repair factors. The investigators have identified nine previously unknown factors involved in the process of cellular DNA repair.

  6. Of quirky channels and a fond farewell

    This final installment of Generally Physiological concerns F-selective channels, a surprising role for a tryptophan in determining channel identity, and a farewell note from the Executive Editor of The Journal of General Physiology.

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