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Center for Physiology and Biophysics: News of the Day
  1. Wide heads help sperm swim together
    Researchers used machine learning to discover that sperm with a wide head relative to length are more likely to clump together and swim collectively, a rare behavior that sometimes helps them reach an egg faster. The study provides a new method for understanding how form and function are related in cells with complex behaviors in all animals, including humans.

  2. An estrogen receptor that promotes cancer also causes drug resistance
    Cancer cells proliferate despite a myriad of stresses -- from oxygen deprivation to chemotherapy -- that would kill any ordinary cell. Now, researchers have gained insight into how they may be doing this through the downstream activity of a powerful estrogen receptor. The discovery offers clues to overcoming resistance to therapies like tamoxifen that are used in many types of breast cancer.

  3. Breast cancers: Ruptures in cell nuclei promotes tumor invasion
    When cells multiply and migrate, they can be compressed and their nucleus may break open. This phenomenon causes DNA damage. Scientists have now shown that this facilitates the spread of cancer cells in breast tumors.

  4. Deadly virus?s pathway to infect cells identified
    Researchers have discovered how Rift Valley fever virus enters cells, pointing the way to new therapies to treat deadly Rift Valley fever.

  5. How poxviruses multiply
    Poxviruses have found a unique way of translating their genes into proteins in the infected organism. Scientists of the have been able to gain atomic-level insights into the functioning of the molecular machinery involved in the process.

  6. Of quirky channels and a fond farewell

    This final installment of Generally Physiological concerns F-selective channels, a surprising role for a tryptophan in determining channel identity, and a farewell note from the Executive Editor of The Journal of General Physiology.

(a) Bordetella pertussis...



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