Mitochondria are the powerhouses of our cells, generating energy that supports life. A giant molecular proton pump, called complex I, is crucial: It sets in motion a chain of reactions, creating a proton gradient that powers the generation of ATP, the cell's fuel. Scientists have solved the mystery of how complex I works: Conformational changes in the protein combined with electrostatic waves move protons into the mitochondrial matrix.
Of quirky channels and a fond farewell
This final installment of Generally Physiological concerns F–-selective channels, a surprising role for a tryptophan in determining channel identity, and a farewell note from the Executive Editor of The Journal of General Physiology.
(a) Bordetella pertussis...