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Center for Physiology and Biophysics: News of the Day
  1. Commonly used antibiotic shows promise for combating Zika infections
    Researchers used a variety of advanced drug screening techniques to test out more than 10,000 compounds in search of a cure. To their surprise, they found that the widely used antibiotic methacycline was effective at preventing brain infections and reducing neurological problems associated with the virus in mice.

  2. CRISPRi screens reveal sources of metabolic robustness in E. coli
    Metabolic robustness, the ability of a metabolic system to buffer changes in its environment, is not always a welcome feature for microbiologists: it interferes with metabolic engineering or prevents that antibiotics kill bacteria. Therefore it is important to understand the mechanisms that enable metabolic robustness. A massively parallel CRISPRi screen demonstrated that E. colimetabolism is very robust against knockdowns of enzymes, and multi-omics data revealed the mechanisms behind it. In t...

  3. Lung-on-chip provides new insight on body's response to early tuberculosis infection
    Scientists have developed a lung-on-chip model to study how the body responds to early tuberculosis (TB) infection.

  4. Enzymatic photocaging for the study of gene regulation through DNA methylation
    The addition and removal of methyl groups on DNA plays an important role in gene regulation. In order to study these mechanisms more precisely, a team has developed a new method by which specific methylation sites can be blocked and then unblocked at a precise time through irradiation with light (photocaging).

  5. World's first: Drug guides stem cells to desired location, improving their ability to heal
    Scientists have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy -- a scientific first and major advance for the field of regenerative medicine.

  6. Of quirky channels and a fond farewell

    This final installment of Generally Physiological concerns F-selective channels, a surprising role for a tryptophan in determining channel identity, and a farewell note from the Executive Editor of The Journal of General Physiology.

(a) Bordetella pertussis...



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