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Center for Physiology and Biophysics: News of the Day
  1. Velcro-like cellular proteins key to tissue strength
    Where do bodily tissues get their strength? New research provides important new clues to this long-standing mystery, identifying how specialized proteins called cadherins join forces to make cells stick -- and stay stuck -- together. The findings could lead to more life-like artificial tissues and tumor busting drugs.

  2. How a plant regulates its growth
    Plants grow in two directions: the shoots of plants grow toward the light to make the best use of it, and the roots grow toward the center of the earth into the soil. A team has now been able to describe in detail how the molecular mechanisms work that control these processes.

  3. Identified: A mechanism that protects plant fertility from stress
    As temperatures rise due to global warming the need to protect plants from stressful conditions has increased, as stress can cause a loss in yield and cause further impact economically. Researchers have successfully identified two proteins that protect crops from stress, which is key in safeguarding food production.

  4. Searching for novel targets for new antibiotics
    Ribosome formation is viewed as a promising potential target for new antibacterial agents. Researchers have gained new insights into this multifaceted process. The formation of ribosomal components involves multiple helper proteins which, much like instruments in an orchestra, interact in a coordinated way. One of these helper proteins - protein ObgE - acts as the conductor, guiding the entire process.
    Measuring the tRNA world
    Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but measuring the amount of each tRNA in cells has been limited by technical challenges. Researchers have now overcome these limitations with mim-tRNAseq, a method that can be used to quantify tRNAs in any organism and will help improve our understanding of tRNA regulation in health and disease.

  5. Of quirky channels and a fond farewell

    This final installment of Generally Physiological concerns F-selective channels, a surprising role for a tryptophan in determining channel identity, and a farewell note from the Executive Editor of The Journal of General Physiology.

(a) Bordetella pertussis...



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