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Center for Physiology and Biophysics: News of the Day
  1. A machine learning approach to identify functional human phosphosites
    Scientists have created the largest phosphoproteome resource to date, which is set to help other researchers identify new functionally-relevant phosphosites. The research demonstrates an exciting use for machine learning methods to effectively compile and analyse large phosphorylation related biological datasets. Identifying new functional phosphosites has enormous potential to progress research into many biological processes and diseases.
    The secret to a long life? For worms, a cellular recycling protein is key
    Scientists have shown that worms live longer lives if they produce excess levels of a protein, p62, which recognizes toxic cell proteins that are tagged for destruction. The discovery could help uncover treatments for age-related conditions, such as Alzheimer's disease, which are often caused by accumulation of misfolded proteins.

  2. What blocks bird flu in human cells?
    Normally, bird flu viruses do not spread easily from person to person. But if this does happen, it could trigger a pandemic. Researchers have now explained what makes the leap from animals to humans less likely.

  3. New function for plant enzyme could lead to green chemistry
    Scientists have discovered a new function in a plant enzyme that could inspire the design of new chemical catalysts. The enzyme catalyzes, or initiates, one of the cornerstone chemical reactions needed to synthesize a wide array of organic molecules, including those found in lubricants, cosmetics, and those used as raw materials for making plastics.

  4. RNA modification: Methylation and mopping up
    Researchers have discovered a novel type of chemical modification in bacterial RNAs. The modification is apparently attached to molecules only when cells are under stress, and is rapidly removed during recovery.

  5. Of quirky channels and a fond farewell

    This final installment of Generally Physiological concerns F-selective channels, a surprising role for a tryptophan in determining channel identity, and a farewell note from the Executive Editor of The Journal of General Physiology.

(a) Bordetella pertussis...



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